MyoStim Wound Healing and Regeneration Accelerator (MWHA-1)
Designed treating wounds secondary to peripheral limb ischemia, foot ulcers and other slow healing wounds. Electrodes are placed near the affected area, and on the blood supply routes to the affected area, and stimulation is administered over a course of physician directed treatment. An example of a treatment protocol is one (1) hour sessions for twenty-one (21) days. Our clinical study end point goals are to improve:
• Blood flow by a minimum of 30%
• Foot ulcers healing by 70%.
• Epidermal wound healing by 55%.
• Dermal healing by 22%.
This electrical stimulation therapy can be used alone or in conjunction with injections of adipose derived stem cells (Bioheart) or other angiogenic cells. It is believed that the combination of electrical stimulation and stem cell injections/infusions will be superior to either as stand alone therapies (subject to confirmation in well controlled clinical trials).
INVESTIGATIONAL USE ONLY. NOT AVAILABLE FOR SALE IN THE USA.
Low-intensity Electrical Stimulation in Wound Healing: Review of the Efficacy of Externally Applied Currents Resembling the Current of Injury - Click Here
Proposed Mechanisms of Action
1. Recruits stem cells from bone marrow, fat, muscle and circulating blood to wound site by stimulating the over expression of the stem cell homing signal protein SDF-1.
2. Multiples recruited stem cells to greater quantities at wound site.
3. Increases blood flow at wound site 3X (from recruiting endothelial progenitor cells and increased expression of VEGF).
4. Decreases pain at wound sites.
5. Decrease edema.
6. Debrides necrotic tissue.
7. Attracts neutophils and macrophages.
8. Stimulates receptor sites for growth factors and growth factor expression.
9. Stimulates growth of fibroblasts and granulation tissue.
10. Stimulates neurite growth.
11. Induces epidermal cell migration.
12. Induces repair myoblast cell migration.
13. Prevents post-ischemic oxygen radical mediated damage.
14. Inhibits bacteria.
15. Reduces number of mast cells.
By-pass grafting, stenting, air cuff techniques and other current treatments are ineffective in treating lower limb ischemia and diabetic foot ulcers.
Electrical stimulation is able to cause the release of proteins and the recruitment and differentiation of stem cells that improve blood flow by over 300% and wound healing by 70% over any other known therapy.
MyoStim Pacers holds exclusive rights to three pioneering patents in the field of electrical stimulation that describe with landmark claims the ability to greatly improve blood flow and to heal injured tissues.
The patented Myostim electrical signaling causes sustained over expression of VEGF mRNAs and SDF-1 and recruits endothelial progenitor cells. VEGF mRNAs stimulate angiogensis, the growth of new sprouting collateral blood vessels. SDF-1 stimulates arteriogeneis creating large more mature new arteries with true endothelium linings. Electrical stimulation additionally recruits stem cells and endothelial progenitor cells from bone marrow, fat tissue and circulating blood to participate in building new blood vessels and wound healing. A reverse of polarity and drop of voltage of the electrical signal stimulates differentiation of these recruited cells into blood vessels and tissues required for healing.